HOMA-IR Insulin Resistance Calculator
HOMA-IR Calculation
Calculate HOMA-IR and HOMA-%B (beta-cell function) from fasting glucose and insulin.
Formula
HOMA-IR = (Fasting Insulin [μIU/mL] × Fasting Glucose [mmol/L]) / 22.5. HOMA-%B = (20 × Fasting Insulin) / (Fasting Glucose - 3.5). HOMA-%S = (1 / HOMA-IR) × 100.
Frequently Asked Questions
What is HOMA-IR?
HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a method to quantify insulin resistance and beta-cell function from fasting glucose and insulin levels. It was developed by Matthews et al. in 1985 and is widely used in research and clinical practice.
What is a normal HOMA-IR value?
Optimal HOMA-IR is below 1.0. Values below 1.9 are generally considered normal. Values between 1.9 and 2.9 suggest early insulin resistance, and values above 2.9 indicate significant insulin resistance. However, reference ranges may vary by laboratory and population.
What is HOMA-%B?
HOMA-%B estimates beta-cell function as a percentage. Normal values are around 100%. Values below 100% suggest declining beta-cell function, which may indicate progression toward type 2 diabetes. Values above 200% may suggest compensatory hyperinsulinemia in response to insulin resistance.
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