FullCalculator

Mass Spectrometry m/z Calculator

Calculate m/z Ratio

m/z = (M ± n×H) / z for ESI

Molecular Weight from m/z

Calculate MW from observed m/z peak

Charge State Envelope

Calculate m/z for multiple charge states

Mass Accuracy (ppm)

Calculate mass accuracy in ppm

Formula

m/z = (M + zH)/z (positive ESI) | MW = m/z × z - z × 1.00728 | ppm = ((obs - theo)/theo) × 10⁶

Frequently Asked Questions

What is m/z in mass spectrometry?
m/z (mass-to-charge ratio) is the fundamental measurement in mass spectrometry. It represents the mass of an ion divided by its charge number. For singly charged ions (z=1), m/z equals the molecular mass plus or minus a proton.
How do I calculate molecular weight from ESI mass spectra?
For positive ESI: MW = (m/z × z) - z × 1.00728 (proton mass). For multiply-charged ions, use two adjacent peaks: MW = z₂(m/z₂ - 1.008) where z₂ = (m/z₁ - 1.008)/(m/z₁ - m/z₂).
What is mass accuracy in ppm?
Mass accuracy (ppm) = ((observed - theoretical) / theoretical) × 10⁶. High-resolution instruments (Orbitrap, FTICR) achieve <5 ppm, while TOF instruments typically achieve 5-20 ppm.

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